Mucinex and flonase. Flonase is a nasal corticosteroid We compare the side effects and drug effectiveness of Flonase allergy relief and Mucinex. Mucinex helps loosen mucus in the chest, while Flonase reduces nasal inflammation. We would like to show you a description here but the site won’t allow us. Customer: Can I use these three medicines together (the day and nighttime mucinex at different times)? In other words will Flonase have any adverse reactions with either of the Mucinex medication? Is childrens mucinex (guaifenesin) okay with flonase? A doctor has provided 1 answer Dr. What is Mucinex d? Mucinex d has active ingredients of guaifenesin; pseudoephedrine hydrochloride. Mucinex Mucinex (guaifenesin) is used to relieve the symptoms of cough and loosen mucus in the chest. . Of the total drug Flonase Interactions There are 53 drugs known to interact with Flonase (fluticasone nasal), along with 5 disease interactions. Flonase Interactions There are 53 drugs known to interact with Flonase (fluticasone nasal), along with 5 disease interactions. Yes, they both can be safely used together. rzq, tvx, idu, bza, vra, auo, vca, uxr, adi, zpv, nin, bdr, cot, trl, wsa,